Prophylactic Nipple-Sparing Mastectomy and Immediate Breast Reconstruction in Chinese BRCA1/2 Carriers: A Case Series with 45-Month Follow-Up and Zero Breast Cancer Incidence

Nipple-sparing prophylactic bilateral mastectomy (NSM) dramatically decreases the risk of breast cancer in healthy women with germline BRCA1/2 pathogenic variants (PVs). Unlike Western BRCA1/2 carriers, data regarding this procedure for Chinese healthy women with BRCA1/2 PVs are currently lacking. This may be attributed to many factors, including the incomplete nationwide availability of BRCA1/2 gene testing and lack of precise risk estimate, Chinese culture, and limited reconstruction accessibility. Here, we report nine highly selected Chinese BRCA1/2 carriers with a strong desire and family cancer history who underwent this procedure.