@article{GS6473,
author = {Qiang Chen and Xiu-He Zou and Tao Wei and Qiu-Shi Huang and Ying-He Sun and Jing-Qiang Zhu},
title = {Prediction of ipsilateral and contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma: a retrospective study},
journal = {Gland Surgery},
volume = {4},
number = {4},
year = {2015},
keywords = {},
abstract = {Background: Prophylactic central lymph node dissection (CLND) in patients with papillary thyroid carcinoma (PTC) remains controversial and predictive factors for central lymph node (CLN) metastasis in unilateral PTC cases are not well defined. The aims of this study were to evaluate the rate of ipsilateral and contralateral CLN metastasis and to determine the clinicopathologic factors predictive for ipsilateral and contralateral CLN metastasis in unilateral PTC cases.
Methods: We retrospectively reviewed 218 PTC patients with clinically negative-node neck who have received total thyroidectomy with bilateral CLND. Pearson χ2 test or Fisher exact test and multivariate analysis were used to evaluate relationships between CLN metastasis and demographic factors such as age, sex and the clinicopathologic factors.
Results: Ipsilateral and contralateral CLN metastasis were present in 47.7% (104/218) and 13.3% (29/218), respectively. Multivariate analysis showed that tumor size (>1 cm) (P=0.016; OR, 2.005) and age 1 cm and especially, if there exists prelaryngeal LN or ipsilateral CLN metastasis on frozen section analysis.},
issn = {2227-8575}, url = {https://gs.amegroups.org/article/view/6473}
}