We are proud to present this special issue dedicated to the most recent development in the follow-up, prevention and management of complications due to thyroid surgery, which represents a comprehensive and extensive collection of information regarding all aspects of the patient’s management including selection and preparation of the patient, informed consent, anesthesiological aspects, the progress in surgical techniques such as endoscopic thyroidectomy and technological tools used for the prevention of the most common complications (intraoperative PTH and neuromonitoring IONM), surgery extension in case of malignant cancer and the treatment of any complications including those that are rarely described in literature.