It is my great pleasure to present the Readers another focused issue of Gland Surgery dedicated to novel technologies in endocrine surgery. Optimal care for endocrine diseases is provided in a multidisciplinary manner. However, surgery remains the base of radical treatment in many endocrine disease entities. Current progress in endocrine surgery can be consider in several dimensions including improved preoperative workup, availability of alternative non-surgical treatment options for selected patients, widespread use of minimally invasive surgical approaches, development of tools for intraoperative quality control of surgery and advances leading to optimized patients’ pathways in the health care system.